Keeffe joined the GIANTS ahead of the 2018 season after playing 40 games over seven seasons for Collingwood. Picked up as a delisted free agent, Keeffe was sought after by the GIANTS due to his versatility, with the athletic 204cm utility able to play as a key defender, a third key-tall, or as a back-up ruckman. Since his move to the GIANTS, Keeffe continues to play a number of roles, with his best season to date coming in 2022 where he played 18 games as a reliable key-position pillar. After playing 14 games in 2023 as a key forward and back-up ruck, Keeffe played predominantly in the VFL throughout the 2024 season until breaking his way into the side in round 22 where he held his spot to play the final five games of the year, including the club’s Qualifying Final against the Swans as well as the Semi-Final with the Lions. In October 2024, Keeffe signed a new one-year deal with the club to play on in 2025.
