The Dees reaffirmed their status as the team to beat yet again this season, proving too classy for the GIANTS at Manuka Oval, recording a 15.9 (99) to 3.4 (22) victory.
Melbourne captain Kate Hore put together one of the best first quarters in recent memory, booting three goals and racking up 13 disposals and five marks.
The GIANTS defence had no answers for the Dees skipper, who ran rampant all evening and became just the second Demon after former skipper Daisy Pearce to kick five goals in a game.
The GIANTS got off to the perfect start with Georgia Garnett steaming into the open goal after the GIANTS won the centre clearance in textbook fashion, but two Hore goals within a minute gave Melbourne the lead and they never looked back.
The Dees booted three unanswered goals in the second term, dominating the contested possession count (135-109) and winning the clearance battle (35-22).
The GIANTS got the first goal of the second half through Alicia Eva but they were unable to convert their solid play into scoreboard reward.
Melbourne flexed their muscle in the final quarter, booting seven unanswered goals to run over the top of the GIANTS.
Nicola Barr - in her 50th game - had a team-high 24 touches while Rebecca Beeson, Alyce Parker and Tarni Evans continued their strong starts to the season.
Up next
The GIANTS will look to bounce back against the Tigers at Blacktown International Sports Park at 1:05pm AEST on Saturday.
GIANTS 2.1 2.1 3.3 3.4 (22)
MELBOURNE 4.1 7.5 8.7 15.9 (99)
GOALS
GIANTS: Garnett, Doyle, Eva
Melbourne: Hore 5, Bannan 3, Purcell 2, Lampard 2, Zanker, Mackin, Mithen
BEST
GIANTS: Barr, Eva, Evans, Parker, Beeson
Melbourne: Hore, Lampard, Hanks, Pearce, Purcell
INJURIES
GIANTS: Nil
Melbourne: Nil
LATE CHANGES
GIANTS: Annalyse Lister (calf) replaced in selected side by Caitlin Miller
Melbourne: Nil
